Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment (Popescu A & German M)

A unique approach to physiological roles of vitamin K2 has been presented in a review article published not long ago in Nutrients. Based on a constantly expanding body of evidence, the authors demonstrated that vitamin K2 could potentially slow down the progression of Alzheimer’s disease (AD) and its supplementation may decrease the likelihood of developing this debilitating disability.

Their research was particularly focused on the antiapoptotic and antioxidant effects of vitamin K2 and its abilities to reduce neuroinflammation and neurodegeneration, rescue mitochondrial dysfunction, mitigate cognitive impairment, and beneficially influence cardiovascular health. Moreover, the researchers also examined the impact of vitamin K2 on comorbidities in AD, and the link between dysbiosis and vitamin K2 in the context of the microbiome’s role in pathogenesis of this most common type of dementia.

The authors arrived at a conclusion that it is extremely important to investigate any possible correlations between vitamin K2 levels and AD risk through observational studies and RCTs.

“Vitamin K2 through a variety of mechanisms that have been mentioned in this review, like for instance reducing apoptosis induced by β-amyloid (Aβ), limiting oxidative stress, reversing microglial activation, suppressing neuroinflammation, and protecting cardiovascular health, emerges as a vital nutrient for improving neuronal health,” says Dr. Katarzyna Maresz, president of the International Science and Health Foundation. “So far, large pharmacological trials have failed to find an effective medication to cure or prevent AD, therefore further attempts need to be undertaken to explore the link between vitamin K2 and AD.”



Popescu A, German M. Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment. Nutrients. 2021 Jun 27;13(7):2206. doi: 10.3390/nu13072206.

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