K & D Supps Lower Blood Pressure, Hypertension Risk: New Study

Vitamins D and K have a wide range of versatile homeostatic capacities at the organ, tissue, and cellular levels, and their involvement in calcium homeostasis and cardiovascular health has been well studied so far. Nonetheless, the role of both vitamins in correlation to lowering blood pressure was largely unknown until a very interesting research on the synergistic effect of vitamin D and vitamin K in reducing the risk of hypertension has been conducted by a group of Dutch scientists and described in the Journal of Hypertension.1

The authors used data from the Longitudinal Aging Study Amsterdam (LASA), a population-based, prospective cohort with baseline measurements obtained between 2002 and 2003 and 3 follow-up exams. The level of 25(OH)D (25-hydroxyvitamin D) and dp-ucMGP (dephosphorylated, uncarboxylated matrix Gla protein, which is an established marker of vitamin K2 status) was measured in serum samples from 257 men and women, aged 55 to 65 years free of prevalent cardiovascular disease, hypertension, and use of anti-hypertensive medication.  The correlation between incident hypertension and the level of vitamin D3 and K2 deficiency marker was evaluated through 2012.

During a median follow-up of 6.1 years, 52% of the cohort developed hypertension. The low level of 25(OH)D < 50 nmol/L and high vitamin K deficiency ( dp-ucMGP ≥310 nmol/L) was associated with a greater hazard ratio for incident hypertension among older adults in the Netherlands.

“Experimental and epidemiological studies suggest that vitamin D deficiency is correlated with the risk of high blood pressure; however, some other studies show that supplementation with vitamin D alone is ineffective against hypertension,” says Dr. Katarzyna Maresz, president of the International Science and Health Foundation. “Synergistic supplementation of chronic kidney disease (CKD) patients with vitamin D3 and K2 is beneficial for their cardiovascular system2, so both vitamins (D3 and K2) might also be efficient to influence the blood pressure. Randomized controlled trials should be planned to evaluate this hypothesis,” Dr. Maresz emphasizes.


1 Van Ballegooijen, Adriana; Van Schoor, Natasja; Brouwer, Ingeborg; Visser, Marjolein; Beulens, Joline. OS 06-09 THE SYNERGISTIC ASSOCIATION BETWEEN VITAMIN D AND VITAMIN K WITH INCIDENT HYPERTENSION. Journal of Hypertension Vol 34, e-Supplement 1, ISH 2016 Abstract Book:e64, September 2016, doi:10.1097/01.hjh.0000500019.61626.b3

2 Kurnatowska I, Grzelak P, Masajtis Zagajewska A, Kaczmarska M, Stefańczyk L, Vermeer C, Maresz K, Nowicki M. Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stage 35. Pol Arch Med Wewn. 2015 Jul 15. pii: AOP_15_066. [Epub ahead of print]


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