Anti-Alzheimer’s properties of vitamin K2 investigated

The number of Americans affected by Alzheimer’s disease (AD) is estimated to rise quickly in the upcoming years and may even reach 13 million people by the year 2050. In the absence of an effective remedy for this debilitating disease, recently some researchers turned toward nonpharmacological interventions and investigated the influence that vitamin K2 may have on factors involved in AD pathogenesis. The results of a broad literature review showing convincing arguments for the anti-Alzheimer’s properties of vitamin K2 have been presented in an article published not long ago in Nutrients.

In their research, the authors focused mainly on the antiapoptotic and antioxidant effects of vitamin K2 and its impact on neuroinflammation, mitochondrial dysfunction, cognition, cardiovascular health, and comorbidities in AD. Moreover, they also examined the link between dysbiosis and vitamin K2 in the context of the microbiome’s role in pathogenesis of this most common type of dementia. The authors emphasized a strong need for future observational studies and RCTs exploring the role of vitamin K2 in AD prevention.

“Vitamin K2 through a variety of mechanisms that have been mentioned in this review, like for instance reducing apoptosis induced by β-amyloid (Aβ), limiting oxidative stress, reversing microglial activation, suppressing neuroinflammation, and protecting cardiovascular health, emerges as a vital nutrient for improving neuronal health,” says Dr. Katarzyna Maresz, president of the International Science and Health Foundation. “So far, large pharmacological trials have failed to find an effective medication to cure or prevent AD, therefore further attempts need to be undertaken to explore the link between vitamin K2 and AD,” she adds.



Popescu A, German M. Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment. Nutrients. 2021 Jun 27;13(7):2206. doi: 10.3390/nu13072206.


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